Key role of heparan sulfate in life-threatening protein-losing enteropathy
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چکیده
منابع مشابه
Heparan sulfate depletion amplifies TNF- -induced protein leakage in an in vitro model of protein-losing enteropathy
Bode, Lars, Erik A. Eklund, Simon Murch, and Hudson H. Freeze. Heparan sulfate depletion amplifies TNF-induced protein leakage in an in vitro model of protein-losing enteropathy. Am J Physiol Gastrointest Liver Physiol 288: G1015–G1023, 2005. First published December 16, 2004; doi:10.1152/ajpgi.00461.2004.—Protein-losing enteropathy (PLE), the excessive loss of plasma proteins through the intes...
متن کاملHeparan sulfate depletion amplifies TNF-alpha-induced protein leakage in an in vitro model of protein-losing enteropathy.
Protein-losing enteropathy (PLE), the excessive loss of plasma proteins through the intestine, often correlates with the episodic loss of heparan sulfate (HS) proteoglycans (HSPG) from the basolateral surface of intestinal epithelial cells. PLE onset is often associated with a proinflammatory state. We investigated whether loss of HS or treatment with the proinflammatory cytokine TNF-alpha dire...
متن کامل[Protein-losing enteropathy].
Protein-losing enteropathy (PLE) is a rare complication of intestinal diseases. Its main manifestation is hypoproteinemic edema. The diagnosis of PLE is based on the verification of protein loss into the intestinal lumen, by determining fecal α1-antitrypsin concentration and clearance. The localization of the affected colonic segment is clarified using radiologic and endoscopic techniques. The ...
متن کاملProtein losing enteropathy in children
Sum mary Protein-losing enteropathy is a medical condition which is characterized by loss of protein, vitamin and trace elements into the intestines which can be complicated by various diseases. The main causes of protein-losing enteropathy in children are primary or secondary intestinal lymphangiectesia, Menetrier disease, inflammatory and immunological disorders. Hypoalbuminemia, developed du...
متن کاملProtein-losing enteropathy in children
Protein-losing enteropathy (PLE) is a rare complication of a variety of intestinal disorders characterized by an excessive loss of proteins into the gastrointestinal tract due to impaired integrity of the mucosa. The clinical presentation of patients with PLE is highly variable, depending upon the underlying cause, but mainly consists of edema due to hypoproteinemia. While considering PLE, othe...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 2009
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.21.41